REDOX-BASED REMODELING OF EXTRA-CELLULAR MATRIX BY MATRIX METALLOPROTEINASES INVOLVING PEROXYNITRITE AND GLUTATHIONE
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چکیده
منابع مشابه
Matrix metalloproteinases and atrial structural remodeling.
Atrial fibrillation (AF) is a common arrhythmia, affecting approximately 5% of the population older than 65 years; the arrhythmia is associated with significant morbidity and mortality, and it is challenging and often frustrating to treat (1,2). There is a tendency for AF to become chronic and more resistant to cardioversion with increasing duration of the arrhythmia (3). Although the details a...
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Cardiovascular disease poses a major health care burden in the Western world. Following myocardial injuries, ventricular remodelling and dysfunction ensue, which can eventually culminate in heart failure. An important event in left ventricular (LV) remodelling is alteration of the extracellular matrix (ECM) integrity, the structural network that interconnects the myocardial components. The crit...
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traumatic brain injury (tbi) results from a sudden and external physical impact to the head, and often leads to motor and cognitive impairment. using tissue engineering strategies, we aimed to review aspects of extra cellular matrix (ecm) based scaffold that could be delivered to the injured brain. the ecm is produced intracellularly and secreted to form a dense network of proteins and glycans,...
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BACKGROUND The proteoglycan biglycan (BGN) is involved in collagen fibril assembly and its fragmentation is likely to be associated with collagen turnover during the pathogenesis of diseases which involve dysregulated extracellular matrix remodeling (ECMR), such as rheumatoid arthritis (RA) and liver fibrosis. The scope of the present study was to develop a novel enzyme-linked immunosorbent ass...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1997
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)41804-0